Torsdag den 20. april 2006  

kl. 17:00 i Aud. 5 på 

H.C. Ørsted Instituttet  

Forårsmøde

High Performance MS  

 

Tilmelding til Frants R. Lauritsen senest fredag den 14. april per Email: frl@kiku.dk.

Alle interesserede er velkomne!  

 

   

17:00  Avanceret ion indfangning i fourier transformerede massespektrometre (FTMS) for både kemisk analyse og gas-fase ion kemi.   

Kim Hasselmann, Kemisk Institut, Syddansk Universitet   

17:45  LC-MS in medicinal Chemistry: Quick, Dirty, Generic – and effective!  

Peter Brøsen, Lundbeck  

18:30  Foreningen er vært ved et lettere traktement med sandwich   og øl/vand. 

 

Abstracts

 Kim Hasselmann, Kemisk Institut, Syddansk Universitet 

Avanceret  ion indfangning i fourier transformerede massespektrometre (FTMS) for både kemisk analyse og gas-fase ion kemi. 

Fourier-transformeret massespektrometri måler frekvenser af cirkulerende ioner i magnetiske og elektriske felter. Via fourier transformationen er det muligt at omsætte frekvenserne til konventionelle massespektrometre med ekceptionel masseopløsning. Foredraget vil fokusere på både gas-fase ion kemi i et fourier transformeret ion cyklotron massespektrometer og analytiske muligheder ved den netop opfundne Orbitrap masse analysator.

 

Peter Brøsen, Lundbeck

LC-MS in medicinal Chemistry: Quick, Dirty, Generic – and effective!

The missing link between the chemists and the biologist on purity issues has finally been resolved with the nearly full automatic LC-MS set-up for analysis and purification. For practical reasons the analytical and preparative system is split up in two separated systems. Both systems are optimised to be as generic as possible and therefore the mass specs are equipped with the latest ion source  APPI. The analytical LC-MS is set-up in an open access environment and is both qualitative and quantitative in an ultra short time. UV or MS trigger the preparative purification. This set-up can purify compounds from 1 to 200 mg in a single run of 7 min. Advanced software scripts have been prepared to handle all data before and after the analysis and purification in an efficient way to fully fit the company database. Data from a combinatorial library will be shown.